Never Give Up

David Baltimore (the Nobel prize winning biologist) reported in a recent address to the American Association for the Advancement of Science that the AIDS virus has evolved in such a way that priming the immune system (the usual goal of a vaccine) appears to be an ineffective plan of attack. Dr. Baltimore went on to say that efforts to create a vaccine have failed leaving “no hopeful route to success” and that “the best hope may lie in the biological equivalent of a Hail Mary pass” or what might best be described as a combination of gene therapy, stem cells, and immunologic therapy to thwart the disease.

This rather bleak assessment of the situation comes in stark contrast to the excitement researchers expressed in 1984 when they predicted that a vaccine would be ready to go to
 
market in three years. But now, 25 years later, the prognosis is grim and every attempt at developing a vaccine has ended in failure leaving some (even one AIDS organization) to conclude that the best way to deal with the pandemic is to give up on a cure altogether and focus our resources on testing, treatment, and prevention. Now that the effort to find a cure seems to have ended in failure, and after a quarter a century of toil and struggle, many in the scientific community are beginning to “lose faith” in the possibility of an all encompassing cure; but to them we say—giving up is not an option.

As it stands over 22 million people have already died from AIDS and the numbers are only growing. Right now there are 42 million people living with HIV/AIDS and 74% of them live in sub-Saharan Africa. By the year 2010 five countries (Ethiopia, Nigeria, China, India, and Russia which make up 40% of the world’s population) will add 50 to 70 million people to the numbers of those already severely infected. And if that were not enough, 14,000 people are infected every day. That’s 14,000 new cases of infection happening every single day in both the industrial and developing world.

Anyone could understand how the recent failure of health officials to develop a vaccine is a disconcerting reality to say the least, but this is not a time for us to lose perspective. In spite of how we feel about the lack of significant progress in this regard, we must resist the temptation to take the situation out of context; because while it is true that AIDS is a rather new phenomenon, the fight against infectious diseases, however, is not.

Take for instance the battle against Polio. We now know that Polio was first detected in the United States in 1921 but a vaccine to cure the dreaded disease was not developed until 1955. It took 34 years for researchers to develop a successful treatment and at no point in the journey was the process easy or immediately successful. And while it is true that AIDS is more of a pandemic than Polio seems to have been, it is no less the case that the fight against Polio exacted the same amount of courage and commitment that the battle against AIDS seems to be demanding from researchers today.

What about the Bubonic Plague? Here is a disease that began in the 14 century but a vaccine wasn’t developed until the middle of the 20th century. For nearly six hundred years courageous men and women dedicated their lives to the singular vision of eradicating “the black death” from the face of the earth. And were it not for their generational commitment to the possibility of human flourishing, millions of people might still be needlessly suffering.

Just like AIDS there are ways to prevent the Bubonic Plague, but the ability to prevent something should never be substituted for the capacity to cure it altogether. Each comes with its own reward, but having one without the other has not (at least not in the case of AIDS) prevented the death of millions of people around the world.

Yes we can prevent AIDS, but the development of a vaccine will not only protect us from the virus, it will, in a manner of speaking, protect us from ourselves. AIDS is a uniquely human reality because the virus is linked to some of the central elements of our humanity, namely, sexuality, addiction, lust, and perhaps most of all indiscretion. And it is in this sense that AIDS is a true pandemic (from the Greek, Pan meaning: all and Demos meaning: people) because every human being has within them the capacity for infection regardless of race, gender, class, and sexual orientation. We are all so tragically human and the possibility of making a mistake is ever before us. It is in many respects an inescapable reality and trying to use prevention as the only way to fight against AIDS is like trying to stop people from arguing by preventing them to talk. It might work but it just isn’t likely.

This is what makes the conundrum of AIDS such as complex situation. We aren’t just fighting against the mutating configurations of the virus itself, we are also battling human nature, human fallibility, the seductive influence of addiction and desire. And while it is true that everybody makes a mistake, it is no less the case that nobody should have to die for it.

Maybe health officials and researchers should begin to see their work as less a matter a science and more a matter of faith. Not faith in a God or some other transcendent reality, but faith in the possibilities of persistence. And maybe with a little faith in spite of the facts some unknown scientist in some distant part of the world might be inspired to advance the cause for a cure and bring hope to millions of people across the globe.

Perhaps members of the scientific community could learn a little something from those of us who believe in something other science; because it is becoming increasingly clear that the race to find a cure will depend on another distinctly human capacity, namely, the capacity to hope. The situation is so dyer that we must leverage all of our ingenuity and genius in the effort to find a cure. And while it is true that we are indeed fallible creatures full indiscretions and vices, it is no less the case that the great gift of our humanity is the capacity to be greater than the sum of our parts.

This is not a call to religion because hope has no particular religious affiliation. And besides, at this point in the struggle we don’t need any more ideologies getting in the way. What we need now are inspired people who (either in service to their religion or by way of some other motivating factor) believe that healing is possible, that you never know what tomorrow will bring, and that our best days are still ahead of us.

To all the researchers currently working to find a cure for AIDS we simply say, “just when the caterpillar thought it was over--she became a butterfly.” Never give up!

 

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Comments

  • 5/16/2008 3:26 AM Iris wrote:
    Mr. McMillan, you have conveyed an important, crucial problem to its light. I am currently working abroad and the appalling dreariness of this disease is indescribable. A lot of people fail to comprehend the importance of being a global citizen. It doesn’t matter where we are, we have a responsibility to care for and support one another, whether it is in Ghana or Chicago. Your informative analysis on scientists and their work towards a cure is very thorough. It’s sad to see how scientists have tried to capsize God’s authority. How life-changing and brilliant it would be if they could see God for who He has been, who He is, and how He’ll remain the same powerful God. My suggestion is that you position this specific article in other informative sources geared towards international issues, or speak out more about this essential subject, especially within inner-city communities. It is greatly needed.
    Reply to this
  • 5/16/2008 12:50 PM Mileece wrote:
    My religion is very simple. My religion is kindness."
    -- The Dalai Lama

    "The flower of kindness will grow. Maybe not now, but it will some day.
    And in kind that kindness will flow, for kindness grows in this way."
    -- Robert Alan

    "Be the change you want to see in the world."
    -- Mohandas Gandhi.

    The first "cure" begins where only God can search, our hearts. For who can know the heart? It's not the highly trained cardiologist, but Skillful God, who performs no fail bi-pass surgery.

    We'll find a cure someday. Compassion, persistence,and tenacity!
    Reply to this
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